Description
A ligand for α5 subunit-containing GABAA receptors that has nootropic activity; selectively binds to α5 subunit-containing GABAA receptors over α1, α2, or α3 subunit-containing receptors (Kis = 1, 70, 48, and 31 nM, respectively, for recombinant human receptors); increases the amplituted of EPSPs in mouse hippocampal slices at 10 nM; decreases the latency to find the platform and increases time spent in the target quadrant in the Morris water maze in mice