(2R)-Octyl-α-hydroxyglutarate from Cayman Chemical

Product Specs
Item(2R)-Octyl-α-hydroxyglutarate
CompanyCayman Chemical
Price $154.00Supplier Page View Company Product Page
Catalog Number16366
FormatA crystalline solid
Research AreaCancer, Metabolism, Neuroscience
Molecular Weight260.3
Quantity5 mg
Purity≥95%
Storage-20
FormulaC13H24O5
OriginUSA

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expressionNatureFebruary 4, 2026Siva Kumar Natarajan, Joanna Lum, James Haggerty Skeans, Minal Nenwani, Sanjana Eyunni, Mateus Mota, Jill M. Bayliss, Akash Deogharkar, Erin Taya Hamanishi, Matthew Pun, et al.250, 500, 1,000, 2,000, 5,000 or 10,000 µM) of itaconic acid (Sigma-Aldrich, I29204), D-2G (Cayman, 16366) or L-2HG (Cayman, 16367). For enzymatic activation, KDM5 enzyme at different concentrations (1.5, 3.0,

(2) Hypoxia Induces Immunosuppression by Silencing STING in CancerCancer ResDecember 1, 2025Yuhong Lu, Annali M. Yurkevicz, Yanfeng Liu, Peter M. Glazerlines were used in this study. Reagents. (2R)-octyl-alpha-hydroxyglutarate (Cayman Chemical, Cat#: 16366); Poly(dA:dT)/LyoVec™ (Invivogen, Cat#: tlrl-patc); ISD/LyoVec™ (Invivogen, Cat#: tlrl-isdc); Poly(I:C)

(3) Hypoxia Induces Immunosuppression by Silencing STING in CancerCancer ResearchDecember 1, 2025Yuhong Lu, Annali M. Yurkevicz, Yanfeng Liu, Peter M. Glazerlines were used in this study. Reagents. (2R)-octyl-alpha-hydroxyglutarate (Cayman Chemical, Cat#: 16366); Poly(dA:dT)/LyoVec™ (Invivogen, Cat#: tlrl-patc); ISD/LyoVec™ (Invivogen, Cat#: tlrl-isdc); Poly(I:C)

(4) Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosisCancer CellJune 9, 2025Derek Dang, Akash Deogharkar, John McKolay, Kyle S. Smith, Pooja Panwalkar, Simon Hoffman, Wentao Tian, Sunjong Ji, Ana P. Azambuja, Siva Kumar Natarajan, et al.Bioscience),Cat#A18420 Elesclomol,Selleck,Cat#S1052 PTC-028,MedChemExpress,Cat#HY-103696 2-deoxy-D-Glucose,Cayman Chemicals,Cat#14325 (2R)-Octyl-α-hydroxyglutarate,Cayman Chemicals,Cat#16366 Ammonium tetrathiomolybdate,Sigma,Cat#323446 ,, Critical Commercial Assays,, LentiStarter 3.0 Kit,System

(5) Inactivation of the SLC25A1 gene during embryogenesis induces a unique senescence program controlled by p53Cell Death & DifferentiationDecember 29, 2024Anna Kasprzyk-Pawelec, Mingjun Tan, Raneen Rahhal, Alec McIntosh, Harvey R. Fernandez, Rami M. Mosaoa, Lei Jiang, Gray W. Pearson, Eric Glasgow, Jerry Vockley, et al.purchased from Sigma (TRCN0000232825; TRCN0000255350) and validated before (6,18,27). Octyl-2-HG (Cayman 16366, 16367) was diluted in PBS pH 7.2. NMN was purchased form Selleckchem (S5259) and DCA from Sigma (347795). Mice The

(6) Inhibition of fatty acid oxidation enables heart regeneration in adult miceNatureOctober 1, 2023Li X, Wu F, Günther S, Looso M, Kuenne C, Zhang T, Wiesnet M, Klatt S, Zukunft S, Fleming I, et al.11969); octyl-αKG 500 μM (Cayman, 11970); CPI-HCl 25 μM (Selleckchem, S8287); R2HG 500 μM (Cayman, 16366). Kdm5b knockdown was achieved through transfection of pooled Kdm5b short interfering RNA (Dharmacon)

(7) 2-Hydroxyglutarate destabilizes chromatin regulatory landscape and lineage fidelity to promote cellular heterogeneityCell reportsJanuary 11, 2022Kusi M, Zand M, Lin LL, Chen M, Lopez A, Lin CL, Wang CM, Lucio ND, Kirma NB, Ruan J, et al.proteins","Chemicals, peptides, and recombinant proteins" (2R)-Octyl-α-hydroxyglutarate,Cayman Chemical,Cat# 16366; CAS# 1391194-67-4 (2S)-Octyl-α-hydroxyglutarate,Cayman Chemical,Cat# 16367; CAS# 1391194-64-1 Dimethyloxalylglycine

(8) R-2HG downregulates ERα to inhibit cholangiocarcinoma via the FTO/m6A-methylated ERα/miR16-5p/YAP1 signal pathwayMolecular therapy oncolyticsDecember 17, 2021Gao Y, Ouyang X, Zuo L, Xiao Y, Sun Y, Chang C, Qin X, Yeh S.be mycoplasma negative as detected by PCR. QBC939 and HuCCT1 cells were treated with 300 μM R-2HG (#16366, Cayman Chemical, Ann Arbor, MI, USA) for the indicated time points. CRISPR-Cas9-mediated IDH1 editing The

(9) Control of endothelial quiescence by FOXO-regulated metabolitesNature cell biologyApril 1, 2021Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, et al.during the first three passages. Cell treatments Cell-permeable (2R)-octyl-α-hydroxyglutarate (R-2HG; 16366) and (2S)-octyl-α-hydroxyglutarate (S-2HG; 16367) from Cayman Biochemical were reconstituted in dimethylsulfoxide

(10) Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in ChondrosarcomaCancers (Basel)November 30, 2020Sanne Venneker, Alwine B. Kruisselbrink, Zuzanna Baranski, Ieva Palubeckaite, Inge H. Briaire-de Bruijn, Jan Oosting, Pim J. French, Erik H. J. Danen, Judith V. M. G. BovéeCayman Chemical, Ann Arbor, MI, USA), the cell permeable derivative of D-2-HG ((2R)-Octyl-α-hydroxyglutarate, 16366, Cayman Chemical), the HDAC inhibitor romidepsin (S3020, Selleckchem), the glutamate dehydrogenase inhibitor

(11) Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine GliomasCancer cellSeptember 14, 2020Chung C, Sweha SR, Pratt D, Tamrazi B, Panwalkar P, Banda A, Bayliss J, Hawes D, Yang F, Lee HJ, et al.(2-Deoxy-D-glucose),Cayman Chem.,Cat# 14325 D-2HG ((2R)-Octyl-α-hydroxyglutarate),Cayman Chem.,Cat# 16366 CB-839,Cayman Chem.,Cat# 22038 BPTES,Cayman Chem.,Cat# 19284 Lonidamine,Cayman Chem.,Cat# 14640 Ketoconazole,Cayman

(12) Wild-type IDH2 contributes to Epstein-Barr virus-dependent metabolic alterations and tumorigenesisMolecular metabolismJune 1, 2020Shi F, He Y, Li J, Tang M, Li Y, Xie L, Zhao L, Hu J, Luo X, Zhou M, et al.Octyl-α-ketoglutarate (octyl-α-KG) and octyl-α-hydroxyglutarate (octyl-2-HG) were from Cayman (Cat: 11970 and 16366, Ann Arbor, MI, USA). AGI-6780 and MG132 were purchased from MedChemExpress (Cat: HY-15734 and HY-13259,

(13) Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomasScience AdvancesApril 24, 2020Yuxiang Wang et al.The final solutions were prepared fresh before each injection. For 2-HG treatment, Octyl-d-2-HG (no. 16366, Cayman Chemical, MI) was initially diluted into DMSO and further diluted with culture medium to achieve

(14) Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation StatusCancersDecember 2, 2019Venneker S, Kruisselbrink AB, Briaire-de Bruijn IH, de Jong Y, van Wijnen AJ, Danen EHJ, Bovée JVMG.Selleckchem) were dissolved in DMSO. The cell permeable derivative of D-2-HG, (2R)-Octyl-α-hydroxyglutarate (16366, Cayman Chemical), was dissolved in phosphate buffered saline (PBS). Doxorubicin (2 mg/mL in 0.9% NaCl)

(15) Radiotherapy resistance in chondrosarcoma cells; a possible correlation with alterations in cell cycle related genesClinical Sarcoma ResearchDecember 1, 2019Yvonne de Jong, Martha Ingola, Inge H. Briaire-de Bruijn, Alwine B. Kruisselbrink, Sanne Venneker, Ieva Palubeckaite, Bram P. A. M. Heijs, Anne-Marie Cleton-Jansen, Rick L. M. Haas, Judith V. M. G. Bovéeshowed that this leads to a complete inhibition of D-2HG production [18]. (2R)-Octyl-α-hydroxyglutarate (16366, Cayman Chemicals), a cell-permeable derivative of D2-HG, was freshly dissolved in PBS before use and

(16) Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal CancerScientific reportsNovember 8, 2016Colvin H, Nishida N, Konno M, Haraguchi N, Takahashi H, Nishimura J, Hata T, Kawamoto K, Asai A, Tsunekuni K, et al.confluency. Reagents and Antibodies 2HG octylesters were purchased as separate enantiomers, D-2HG octylester (16366, Cayman Chemical Company, MI) or L-2HG octylester (16367, Cayman Chemical Company, MI). The antibodies

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(2R)-Octyl-α-hydroxyglutarate from Cayman Chemical

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Cayman Chemical

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(2R)-Octyl-α-hydroxyglutarate from Cayman Chemical

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