Description
A dopamine receptor antagonist (Kis = 2.4, 0.3, and 1.8 nM for D2, D3, and D4 receptors, respectively); binds to eight additional receptors (Kds = 25-3,100 nM for the human receptors) and inhibits Nav1.2 and Kv11.1 (IC50s = 42 and 340 nM, respectively); decreases the number of licks and reduces fluid intake of a sweetened solution in rats at 0.5, 1, and 2 mg/kg; decreases the number of attacks and threats and increases immobility time in the neutral arena aggression test, indicating increased passiveness, in male mice at 0.75 mg/kg for 10 days