Kinase Screening Library (96-Well) from Cayman Chemical

Product Specs
ItemKinase Screening Library (96-Well)
CompanyCayman Chemical
Price $2,336.00Supplier Page View Company Product Page
Catalog Number10505
FormatA 10 mM solution in DMSO
Research AreaCancer, Cell Biology, Cell Signaling
Quantity50 µL
Storage-20
OriginUSA
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Synthetic super-enhancers enable precision viral immunotherapyNatureApril 8, 2026Ute Koeber, Mantas Matjusaitis, Neza Alfazema, Katharine Furlong, Zeyu Wang, Rachel White, Alhafidz Hamdan, Pooran Dewari, Gregoire Morisse, Mariela Navarette, et al.inhibitor screening E55 cells were screened using inhibitors included in the Kinase Screening Library (Cayman, 10505) as well as two YAP–TEAD pathway inhibitors, MGH-CP1 (HY-139330) and TED-347 (HY-125269). Around 18,000

(2) Screening of kinase inhibitors in the triple negative KRAS G13D-mutated MDA-MB-231 breast cancer cell lineScientific ReportsMarch 11, 2026Sandra Stickler, Marie-Therese Eggerstorfer, Maximilian Rieche, Sinem Arslan, Maryana Teufelsbauer, Martin Hohenegger, Lukas Weigl, Gerhard HamiltonGSK1059615, GSK2334470, CAY10621, Nilotinib, NH125 and LY2606368 were part of a Kinase Screening Library (10505, Cayman Chemical, Ann Arbor, MI, USA) that consists of 157 inhibitors at 10 mM in 50 µl aliquots in

(3) Protein Kinase C promotes peroxisome biogenesis and peroxisome-endoplasmic reticulum interactionJ Cell BiolSeptember 1, 2025Anya Borisyuk, Charlotte Howman, Sundararaghavan Pattabiraman, Daniel Kaganovich, Triana AmenNeuropan 27 Supplement 50× (Pan Biotech), FBS (S100082425; Pan-Biotech), kinase screening library (Cayman, 10505), NP-40 (NP40S; Sigma-Aldrich), sodium deoxycholate (D6750; Sigma-Aldrich), SDS (4360.2; Carl Roth),

(4) MCL‑1 safeguards activated hair follicle stem cells to enable adult hair regenerationNat CommunMarch 22, 2025Hui San Chin, Jinming Cheng, Shih Han Hsu, Guo Guang Lum, Maria Tk Zaldivia, Sarmilla Nelameham, Fusheng Guo, Keerthana Mallavarapu, Felicity C. Jackling, Jicheng Yang, et al.kinase screening library, keratinocytes were cultured with 2 µM of each compound (CAYMAN; 96‑well; item 10505; batch: 0577971) according to the ascending list starting at well A1 to H12 of plate 1 followed by plate

(5) Light-gated integrator for highlighting kinase activity in living cellsNature CommunicationsSeptember 6, 2024Wei Lin, Abhishek Phatarphekar, Yanghao Zhong, Longwei Liu, Hyung-Bae Kwon, William H. Gerwick, Yingxiao Wang, Sohum Mehta, Jin Zhangculturing. For PKA inhibitor screening, cells were treated with kinase inhibitor library (Cayman chemical, #10505-0577971, 10 µM each drug) and blue light for 20 min (10 s on/50 s off), followed by 24 h expression.

(6) Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancerNature CancerJanuary 2, 2024Fuming Li, Pingyu Liu, Wen Mi, Liucheng Li, Nicole M. Anderson, Nicholas P. Lesner, Michelle Burrows, Jacqueline Plesset, Ariana Majer, Guanlin Wang, et al.Table 1. Kinase inhibitor screen. A Kinase Screening Library (96-Well) was purchased from Cayman (#10505). To screen, each well of DMSO and inhibitor stock was diluted into corresponding new 96-well plates

(7) 5-Iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFκB signalingCell death discoveryJuly 26, 2023Chauhan C, Kraemer A, Knapp S, Windheim M, Kotlyarov A, Menon MB, Gaestel M.kinase inhibitors dissolved in DMSO (10 mM stock concentration), was purchased from Cayman Chemicals (#10505). The following reagents were used for cell treatments at given concentrations: LPS (Escherichia coli

(8) 4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone Inhibits MCPyV T Antigen Expression in Merkel Cell Carcinoma Independent of Aurora Kinase ACancersApril 28, 2023Houben R, Alimova P, Sarma B, Hesbacher S, Schulte C, Sarosi EM, Adam C, Kervarrec T, Schrama D.total of 180 different kinase inhibitors (10 μM) included in a library purchased by Cayman Chemicals (10505) were applied to mixtures containing 80% parental MKL-1 cells. After seven days, flow cytometry (Cytoflex;

(9) Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockadeHaematologicaApril 1, 2023Katharina Woess, Sabine Macho-Maschler, Dorette S. Van Ingen Schenau, Miriam Butler, Caroline Lassnig, Daniel Valcanover, Andrea Poelzl, Katrin Meissl, Barbara Maurer, Tania Brandstoetter, et al.Screening). Six hundred and eighty drugs of kinase inhibitor libraries (L1600, Targetmol, Boston, MA, US and 10505, Cayman Chemicals, Ann Arbor, MI, US) were screened at 10 µM in duplicates on 2x103 Ba/F3 TYK2 P760L

(10) A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix AlignmentCancer Research CommunicationsDecember 19, 2022Caitlin E. Jones, Joe T. Sharick, Steven T. Sizemore, Edna Cukierman, Anne Marie Strohecker, Jennifer L. Leightcells were treated with DMSO control or 1 or 10 μmol/L of a kinase inhibitor library (Cayman Chemical #10505, batch no. 0550547), 50 μg/mL ascorbic acid, and 6 μg/mL fluorescently labeled fibronectin (labeling

(11) A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix AlignmentCancer Res CommunNovember 22, 2022Caitlin E. Jones, Joe T. Sharick, Steven T. Sizemore, Edna Cukierman, Anne Marie Strohecker, Jennifer L. Leightcells were treated with DMSO control or 1 or 10 μmol/L of a kinase inhibitor library (Cayman Chemical #10505, batch no. 0550547), 50 μg/mL ascorbic acid, and 6 μg/mL fluorescently labeled fibronectin (labeling

(12) A toolkit for the identification of NEAT1_2/paraspeckle modulatorsNucleic acids researchNovember 11, 2022An H, Elvers KT, Gillespie JA, Jones K, Atack JR, Grubisha O, Shelkovnikova TA.after plating for stable cell lines). Working plates of the Cayman Chemical Kinase Screening library (10505) were prepared by diluting 10 mM stock solutions of compounds in water to 500 μM. For the initial screen,

(13) Reaction-based fluorogenic probes for detecting protein cysteine oxidation in living cellsNature communicationsSeptember 21, 2022Ferreira RB, Fu L, Jung Y, Yang J, Carroll KS.modulate S-sulfenation The ‘Kinase Screening Library’ was purchased from Cayman Chemical (Cat. No. #10505). The library consists of two plates and contains ~160 curated selective and non-selective kinase inhibitors

(14) A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damageNAR Genomics and BioinformaticsSeptember 13, 2022Jianfeng Li, Alison Beiser, Nupur B Dey, Shunichi Takeda, Liton Kumar Saha, Kouji Hirota, L Lynette Parker, Mariah Carter, Martha I Arrieta, Robert W SobolSigma-Aldrich (St. Louis, MO). The kinase inhibitor compound set was purchased from Cayman Chemical (Cat# 10505). All compounds were stored at −20°C until used. The final concentration of each kinase inhibitor used

(15) A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signalingeLifeSeptember 30, 2021Kim M, Reinhard C, Niehrs C.,Recombinant human HGF,Peprotech,100–39 H,50 ng/ml "Chemical compound, drug",Kinase Screening Library (96well),Cayman chemical,10505,500 nM "Chemical compound, drug",Crizotinib,Cayman chemical,12087,500 nM "Chemical compound, drug",Dasatinib,Cayman chemical

(16) Primary Cilia, Ciliogenesis and the Actin Cytoskeleton: A Little Less Resorption, A Little More Actin PleaseFrontiers in Cell and Developmental BiologyDecember 17, 2020Claire E. L. Smith, Alice V. R. Lake, Colin A. JohnsonADPKD cells: gemcitabine, niclosamide, cerivastatin PMID:32144367 mIMCD3 Pkd1−/−b 3D none Cayman Chemicals #10505 (155 kinase inhibitors) 6 day treatment, various concentrations 1-33 µM % cord/tubule vs. cysts (F-actin) treatment

(17) Context specificity of the EMT transcriptional responseNature communicationsMay 1, 2020Cook DP, Vanderhyden BC.inhibitors were used at a final concentration of 1 µM (Cayman Chemical Kinase Screening Library, Item No. 10505, Batch No. 0537554). EMT inducers and kinase inhibitors were refreshed daily after replacing the culture

(18) Small Molecule Screen Reveals Joint Regulation of Stress Granule Formation and Lipid Droplet BiogenesisFrontiers in cell and developmental biologyJanuary 1, 2020Amen T, Kaganovich D.(Roth), phenylmethylsulfonyl fluoride (PMSF, Sigma), Fasnall (Sigma), and kinase screening library (10505, Cayman Chemical). TABLE 1 | Plasmids used in this study. Plasmid name Source Px459-PPAR-KO-gRNA This

(19) The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor DiseaseCancer cellJanuary 14, 2019Kosack L, Wingelhofer B, Popa A, Orlova A, Agerer B, Vilagos B, Majek P, Parapatics K, Lercher A, Ringler A, et al.(Sdelci et al., 2016) and 684 kinase inhibitors (Targetmol catalog no. L1600 and Cayman Chemical item no 10505), which were transferred onto 384-well plates using an acoustic liquid handler (Echo, Labcyte). 5000

(20) A Dual Inhibitor of Cdc7/Cdk9 Potently Suppresses T Cell ActivationFrontiers in immunologyJanuary 1, 2019Chen EW, Tay NQ, Brzostek J, Gascoigne NRJ, Rybakin V.respectively. Kinase inhibitors were obtained from a kinase inhibitor screening library by Cayman Chemical (#10505). PHA-767491, 2-(pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrochloride, was obtained

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Kinase Screening Library (96-Well) from Cayman Chemical

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Cayman Chemical

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Kinase Screening Library (96-Well) from Cayman Chemical

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