RK-287107 from Cayman Chemical

A TNKS1 and TNKS2 inhibitor (IC50s = 0.014 and 0.010 µM, respectively); selective for TNKS1 and TNKS2 over PARP1, PARP2, and PARP10 (IC50s = >20, 2.7, and 19.8 µM, respectively); inhibits Wnt-dependent signaling (IC50 = 0.077 µM in a reporter assay); increases Axin2 accumulation in COLO 320DM cells at 0.1 µM; inhibits cell growth in COLO 320DM cells (GI50 = 0.45 µM); reduces tumor growth in a COLO 320DM mouse xenograft model at 150 mg/kg