Description
A µ-opioid receptor agonist (Ki = 1.1 nM); selective for µ- over κ- and δ-opioid receptors (Kis = 18 and 506 nM, respectively); induces Gi/o signaling (EC50 = 4.6 nM in HEK293T cells expressing human receptors) but has no detectable activity in a β-arrestin2 recruitment assay; induces analgesia in the hot plate test at 10, 20, and 40 mg/kg and reduces formalin-induced paw licking in mice at 40 mg/kg