Description
A natural product and an active metabolite of curcumin; has anti-inflammatory, antioxidant, and anticancer properties; reduces PMA-induced PGE2 production by 37% in human colonic epithelial cells (20 µM); inhibits LPS-induced overproduction of nitric oxide in RAW 264.7 macrophage cells (3.125-25 µM); inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation (50 µM); prevents formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer