Description
A natural inhibitor of p23 chaperone function; inhibits Hsp90 expression in vitro in NTERA-2 cells at 5 µg/ml; binds to and blocks p23 to induce apoptosis in HeLa-PRB cells (20 µM); inhibits breast cancer cell proliferation in vitro (IC50s = 8.84 and 3.22 µM in MCF-7 and SKBr-3 cells, respectively); inhibits PANC-1 pancreatic cancer cell growth in vitro (IC50 = 25 µM); has anti-inflammatory effects in mouse models of articular inflammation when used at doses of 0.05–0.5 mg/kg and allergic inflammation when used at a dose of 0.5 mg/kg; targets LPS binding and TLR4 signaling in macrophages when used at a concentration of 10 µM