Description
A Chk2 inhibitor (IC50 = 13.5 nM); selective for Chk2 over Chk1 (IC50 = 220.4 nM); inhibits Chk2 autophosphorylation at Ser516 in non-cancerous 184B5 cells that contain wild-type p53 and in MDA-MB-231 cells that contain mutated p53 at 0.1-30 µM; enhances survival of 184B5, but not MDA-MB-231, cells following ionizing radiation; inhibits PMA-induced production of IL-2 in Jurkat cells and LPS-induced TNF-α production in THP-1 cells (IC50s = 3.5 and 8.2 µM, respectively); inhibits the growth of CEM leukemia T cells (GI50 = 1.73 µM)