Description
RO9021 is ATP-competative and selective inhibitor of spleen tyrosine kinase (SYK) with IC50 value of 5.6 nM. RO-9021 is a highly selective SYK inhibitor with low S-scores of 0.003 for S(99) and 0.015 for S(90). This indicates that SYK is the only kinase with 99% competition with RO-9021 (1 uM) in a total of 392 tested kinases. RO9021 also can selectively suppress B-cell receptor signaling