Description
HIF pathway activator (EC50 values are 1.23 and 1.4 µM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, µ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 µM