Description
Perlapine, an atypical neuroleptic, is a potent and selective hM3Dq DREADD agonist (EC50 = 2.8 nM) with >10,000-fold selectivity for hM3Dq over hM3. Perlapine blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively)