Description
Inhibitor of gamma-secretase; causes a reduction in Abeta40 and Abeta42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Abeta and Abeta42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPalpha and APPbeta levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation