Description
Vitronectin is a glycoprotein found in plasma and extracellular matrix (ECM). It is a soluble, disulfide-linked dimer, composed of a 75 kDa and a 65 kDa peptide chain. In plasma, vitronectin is predominantly found as a single chain monomer [1]. The N-terminal of vitronectin contains multiple binding sites for a variety of structures. Vitronectin is involved in a number of biological functions including cell adhesion, spreading, migration, proliferation, extracellular anchoring, fibrinolysis, hemostasis, and complement immune defense [2, 3, 4]. Vitronectin can be used for coating tissue culture surfaces to promote cell adhesion, proliferation, and differentiation. ScienCell™ Bovine Plasma Vitronectin is purified from bovine plasma by affinity chromatography [5]. It is supplied as a sterile solution in Dulbecco's Phosphate-Buffered Saline (DPBS). Optimal conditions for cell attachment must be determined for each cell line and application. Product Specification Quantity: 100 µg Concentration: 0.4 mg/ml Storage buffer: DPBS, pH 7.4