Description
Endomucin (endothelial sialomucin; also Endomucin-1/2 and Mucin-14) is an 80-120 kDa glycoprotein member of the Endomucin family of proteins. It is expressed on endothelial cells and depending upon its glycosylation pattern, can serve as either a pro- or anti-adhesive molecule. Mouse Endomucin precursor is 261 amino acids in length. It is a type I transmembrane protein that contains a 170 aa extracellular domain (ECD) (aa21-190) and a 50 aa cytoplasmic region. Three splice variants exist in the ECD. One shows a deletion of aa91-141, a second shows a one aa substitution for aa91-129, and a third shows a one aa substitution for aa129-142. Over aa21-90, mouse Endomucin shares 60% and 30% aa identity with rat and human Endomucin, respectively