Recombinant Human IL-21 Protein 8879-IL-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human IL-21 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $322.00Supplier Page View Company Product Page
Catalog Number8879-IL-010
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human IL-21 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, <= -20 °C under sterile conditions after reconstitution
NCBI Gene AliasesZa11, IL-21, CVID11
NCBI Full Gene Nameinterleukin 21
Molecule NameIL-21
SpeciesHuman
Molecular WeightObserved: 17 kDa, reducing conditions
Theoretical: 15 kDa
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Size10 ug (also 50 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Organ injury in systemic autoimmunity is mediated by stem-like CD8+ T cells arising from tissue-draining lymph nodesImmunityApril 20, 2026Jafar Al Souz, Yulong Wei, Can Cui, Rihao Qu, Jin-Young Choi, Fang Wang, Steven J. Moioffer, Julia Barrett, Irene Chernova, Manvitha Nadella, et al."Recombinant Human IL-15 Protein, CF",R&D Systems,Cat#BT-015-010 Recombinant Human IL-21 Protein with carrier,R&D Systems,Cat#8879-IL-010 FTY720,MilliporeSigma,Cat344597; CAS:162359-56-0 Deoxyribonucleic acid from calf thymus,MilliporeSigma,Cat#D4522;

(2) Engineering of induced pluripotent stem cells for the efficient development of non-alloreactive, hypoimmunogenic CD8αβ CAR-T cellsFrontiers in ImmunologyFebruary 20, 2026Alexandros Nianias, Afroditi Katsarou, Henk Jan Prins, Aida Shahrabi, Cindy van Velzen, Linda Henneman, Ruud Ruiter, Tuna Mutis, Richard Groen, Maria Themeliwith 100 U/mL rhIL-2, 10 ng/mL rhIL-15 (Peprotech, Cat#200-15), and 10 ng/mL rhIL-21 (R&D Systems, Cat#8879-IL-010). For some experiments, NKG2A+ NK cells were kindly offered by the group of Dr. Lotte Wieten (Maastricht

(3) IL-21-STAT3 axis negatively regulates LAIR1 expression in B cellsbioRxiv : the preprint server for biologyJanuary 18, 2025Yoshida K, Kurata-Sato I, Atisha-Fregoso Y, Aranow C, Diamond B.

(4) Potent antitumor activity of a designed interleukin-21 mimicbioRxiv : the preprint server for biologyDecember 7, 2024Chun JH, Lim BS, Roy S, Walsh MJ, Abhiraman GC, Zhangxu K, Atajanova T, Revach OY, Clark EC, Li P, et al.

(5) Antigen-Specific T Cell Receptor Discovery for Treating Progressive Multifocal LeukoencephalopathybioRxiv : the preprint server for biologyNovember 4, 2024Gupta S, Martinov T, Thelen A, Sunahara M, Mureli S, Vazquez A, Gerdts J, Dandekar R, Cortese I, Fouassier C, et al.

(6) Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver diseaseEBioMedicineSeptember 1, 2023Vaikunthanathan T, Landmann E, Correa DM, Romano M, Trevelin SC, Peng Q, Crespo E, Corrado M, Lozano JJ, Pearce EL, et al.

(7) Identification of T Cell Receptors Targeting a Neoantigen Derived from Recurrently Mutated FGFR3CancersFebruary 6, 2023Tate T, Matsumoto S, Nemoto K, Leisegang M, Nagayama S, Obama K, Nakamura Y, Kiyotani K.

(8) PD-1(high)CXCR5(-)CD4(+) peripheral helper T cells promote CXCR3(+) plasmablasts in human acute viral infectionCell reportsJanuary 31, 2023Asashima H, Mohanty S, Comi M, Ruff WE, Hoehn KB, Wong P, Klein J, Lucas C, Cohen I, Coffey S, et al.

(9) CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune ResponseCell transplantationJanuary 1, 2023Cao L, Ma X, Zhang J, Yang M, He Z, Yang C, Li S, Rong P, Wang W.

(10) Serum neutralization activity declines but memory B cells persist after cure of chronic hepatitis CNature communicationsSeptember 16, 2022Nishio A, Hasan S, Park H, Park N, Salas JH, Salinas E, Kardava L, Juneau P, Frumento N, Massaccesi G, et al.

(11) DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cellsScience advancesAugust 26, 2022Michaels YS, Edgar JM, Major MC, Castle EL, Zimmerman C, Yin T, Hagner A, Lau C, Hsu HH, Ibañez-Rios MI, et al.

(12) Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 ReceptorCellsAugust 19, 2022Rode AKO, Buus TB, Mraz V, Al-Jaberi FAH, Lopez DV, Ford SL, Hennen S, Eliasen IP, Klewe IV, Gharehdaghi L, et al.

(13) Na(+)/H(+)-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cellsCancer Res CommunAugust 1, 2022Gong YY, Shao H, Li Y, Brafford P, Stine ZE, Sun J, Felsher DW, Orange JS, Albelda SM, Dang CV.recombinant human IL2 (STEMCELL Technologies, 78036) and 50 ng/mL of recombinant human IL21 (R&D Systems, 8879-IL-010) overnight prior to the addition of concentrated lentiviruses. Cells were incubated with lentiviruses

(14) Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cellsAgingMarch 4, 2022Kim K, Admasu TD, Stolzing A, Sharma A.in RPMI complete media with 100 IU/ml human rIL-2 (recombinant Interleukin-2) (R and D Systems; Cat# 8879-IL-010) before co-culturing with senescent or non-senescent IMR-90 fibroblasts. NK cell characterization Peripheral

(15) Over-Expression of Allograft Inflammatory Factor-1 (AIF-1) in Patients with Rheumatoid ArthritisBiomoleculesJuly 16, 2020Piotrowska K, Słuczanowska-Głabowska S, Kurzawski M, Dziedziejko V, Kopytko P, Paczkowska E, Rogińska D, Safranow K, Machaliński B, Pawlik A.

(16) Association of circulating SLAMF7⁺Tfh1 cells with IgG4 levels in patients with IgG4-related diseaseBMC immunologyJune 1, 2020Higashioka K, Ota Y, Maehara T, Moriyama M, Ayano M, Mitoma H, Akahoshi M, Arinobu Y, Horiuchi T, Nakamura S, et al.

(17) IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissueMucosal immunologyMay 1, 2020Xu R, Shears RK, Sharma R, Krishna M, Webb C, Ali R, Wei X, Kadioglu A, Zhang Q.

(18) B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody responseScience advancesApril 1, 2020Gan H, Shen T, Chupp DP, Taylor JR, Sanchez HN, Li X, Xu Z, Zan H, Casali P.

(19) IL-21 in Conjunction with Anti-CD40 and IL-4 Constitutes a Potent Polyclonal B Cell Stimulator for Monitoring Antigen-Specific Memory B CellsCellsFebruary 13, 2020Franke F, Kirchenbaum GA, Kuerten S, Lehmann PV.

(20) TCDD-mediated suppression of naïve human B cell IgM secretion involves aryl hydrocarbon receptor-mediated reduction in STAT3 serine 727 phosphorylation and is restored by interferon-γCellular signallingJanuary 1, 2020Blevins LK, Zhou J, Crawford R, Kaminski NE.