8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer (Rp-8-CPT-cAMPS) from MyBioSource.com

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8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer (Rp-8-CPT-cAMPS)

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Description

C16H14ClN5O5PS2¢Na; MW 509.8; lambdamax 282 nm; epsilon 16000; sodium salt; purity > 99% HPLC, highly purified, fluorescent impurities removed. For other salt forms please inquire. Lipophilic analog of Rp-cAMPS. Potent competitive inhibitor of protein kinase A type I and II (cyclic AMP antagonist). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Considerably more lipophilic and membrane-permeant compared to Rp-8-Br-cAMPS. Detailed technical information and updated reference list available on request. Reference: Weisskopf et al., Science, 265, 1878 - 1882 (1994)