Description
C10H11N5O6PS.Na; MW 383.3; lambdamax 252 nm; epsilon 14300; sodium salt, purity > 99% HPLC. For other salt forms please inquire. Inhibitor of protein kinase G Ialpha. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. Caution: Both membrane permeability and kinase specificity of this analogue are low. Rp-8-pCPT-cGMPS or Rp-8-Br-PET-cGMPS are much more permeant and selective antagonists! In order to avoid disappointments, please use for permeabilized cells or injection techniques only and make sure that lacking cAMP/cGMP specificity is not a problem. Useful of course for in vitro kinase and phosphodiesterase mapping studies! Detailed technical information and updated reference list available on request. Reference: Butt et al., FEBS Lett., 263, 47 - 50 (1990).
Protected under patents US 5,625,056 & DE 3802865.4 exclusively licensed to BIOLOG LSI