Description
Description: GDNF promotes the survival and differentiation of dopaminergic neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. GDNF enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Image: Immunofluorescence for hN2 Human Neurons Discovery Kit differentiated in the presence of 25 ng/ml GDNF. Cells were also counterstained for nuclei (DAPI) and Tuj 1-Neuron-specific class III beta-tubulin and TH-Tyrosine Hydroxylase. hGDNF Recombinant Protein: Customer Publications