Description
Description: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture.References: 1. Therapies directed against epidermal growth factor receptor in aerodigestive carcinomas. JAMA 2007 Jul 4;298(1):70-822. Epidermal growth factor signaling for matrix-dependent cell proliferation and differentiation in primary cultured hepatocytes. Tissue Eng 2007 Mar;13(3):601-93. Bovine follicular fluid contains antagonist activity for cumulus expansion promoting effect by epidermal growth factor. Reprod Domest Anim 2007 Jun;42(3):225-94. A mutation in CCDC50, a gene encoding an effector of epidermal growth factor-mediated cell signaling, causes progressive hearing loss. Am J Hum Genet 2007 Jun;80(6):1076-895. PEA3 is necessary for optimal epidermal growth factor receptor-stimulated matrix metalloproteinase expression and invasion of ovarian tumor cells. Mol Cancer Res 2007 May;5(5):413-216. Amino-terminal deletion of heparin-binding epidermal growth factor-like growth factor4-127 stimulates cell proliferation but lacks insulin-like activity. Cell Prolif 2007 Apr;40(2):213-30 Image: EGF protein structure and sequence