Description
UBA7 or or ubiquitin-like modifier activating enzyme 7 is a member of the E1 ubiquitin-activating enzyme family which is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. UBA7 is expressed in a variety of tissues, including normal lung, but highly expressed in a large series of lung cancer cell lines. UBA7 may represent a second, autosomal member of the ubiquitin-activating gene family, which play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes