Description
Pulmonary Surfactant-Associated Protein A2 (SFTPA2) is a member of the SFTPA family. SFTPA2 is a secreted protein and contains one C-type lectin domain and one collagen-like domain. In the presence of calcium ions, it binds to surfactant phospholipids and contributes to lowering the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Defects in SFTPA2 are a cause of pulmonary fibrosis idiopathic, and results in acute lung injury with subsequent scarring and endstage lung disease