Description
Mesencephalic astr centigradeyte derived neurotrophic factor (MANF), also known as argininerich, mutated in early stage tumors (ARMET) and argininerich protein (ARP), is a 20 kDa member of the ARMET family of proteins. The name ARMET comes from the fact that the protein was initially thought to be 50 aa longer at the Nterminus and to contain an arginine rich region. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors