Description
This product is the N-terminal extracellular domain of smoothened homolog (SMO). Native SMO is a G protein-coupled receptor that associates with the patched protein (PTCH) to transduce the hedgehog"s proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia