Description
The protein contains different segments for both recognizing and removing opposing methyl groups. While the PHD binds H3K4me3, an alteration associated with transcriptional activation, the Jumonji (catalytic) domain demethylates H3K27me2, a mechanism associated with transcriptional repression. The enzymes" catalytic activity and substrate specificity is thereby enhanced through the simultaneous binding of multiple domains. The ability to apprehend the function of individual methyl marks could lead to a marked understanding of the language of the histone code