Description
Human Sex Determining Region Y Box 2 (Sox2) belongs to a diverse family of structurally-related transcription factors whose primary structure contains a high mobility group box domain. SOX2 is one of the important transcription factors required in induced pluripotent stem cells. SOX2 regulates the expression of multiple genes involved in embryonic development, including FGF-4, YES-1, ZFP206. SOX2 may as a switch in neuronal development, keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. It has been shown SOX2 can interact with PAX6