Description
SLIT and NTRK-Like Protein 3 (SLITRK3) is a member of the SLITRK family that are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins. SLITRK3 contains an N-terminal signal peptide, followed by two LRR domains, a transmembrane domain, and a cytoplasmic domain with a putative tyrosine phosphorylation site. Each LRR domain is flanked by cysteine-rich regions. SLITRK3 is expressed at higher levels in some astrocytic brain tumors such as strocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors