Description
PAPPA is a metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. It belongs to the peptidase M43B family. Contains 5 Sushi (CCP/SCR) domains