Description
The activating transcription factor 2 (ATF2), also known as CRE-BP1 (cAMP-responsive element binding protein 1), is a member of the leucine zipper family of DNA binding proteins and binds to both AP-1 and CRE DNA response elements of many viral and cellular promoters. ATF2 can be activated by a diverse number of cellular stresses such as inflammatory cytokines, genotoxic agents and UV irradiation through MAPK pathway. It is activated through phosphorylation at two phosphosites of Thr69 and Thr71 by upstream activators like JNK/p38 (MAPK14, SAPK2A)