Description
UbiquitinConjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or shortlived proteins for degradation, which belong to the ubiquitinconjugating enzyme family. It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulumassociated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48linked polyubiquitination by UBE2G2/GP78 appears to involve the transfer of preassembled Ub chains from UBE2G2 to lysine residues in a substrate. The E2 and E3 enzymes form a large heterooligomer which brings multiple UBE2G2 molecules into close proximity which allows for Ub transfer between neighboring E2s