Description
Neural Precursor Cell Expressed, Developmentally Downregulated 8 (NEDD8) is a member of the ubiquitin like modifiers and the human gene was first described by (Kamitani, et al., 1997). The heterodimeric E1, APP-BP1/UBA3 forms a complex in vitro and a thioester linkage with NEDD8 (Osaka et al., 1998). NEDD8 has also been co-crystallised with APP-BP1 and ATP (Walden et al., 2003)