Description
Airway Trypsin-Like Protease (HAT) is a single-pass type II membrane protein that belongs to the peptidase S1 family. HAT contains one peptidase S1 domain and one SEA domain. HAT is strongly inhibited by diisopropyl fluorophosphate, leupeptin, antipain, aprotinin and soybean trypsin inhibitor. HAT may play some biological roles in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions