Description
PKD2 or polycystic kidney disease 2 is a member of the polycystin protein family which is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. PKD2 interacts with polycystin 1 and this complex may be partners in a common signaling cascade involved in tubular morphogenesis. PKD2 may function as a chaperone-like molecule, which may prevent ERAD of PKD2. PKD2 form an interaction network with PKD1 as the rate-limiting component