Description
OTUB1 was recently shown to modulate p53 stability through inhibition of UBE2D1. p53 is known to be ubiquitylated and destabilized by MDM2 and several other ubiquitin E3s and both deubiquitylated and stabilized by USP7 and USP10. Recent studies have shown that OTUB1 can directly suppress MDM2-mediated p53 ubiquitylation in cells and in vitro. Overexpression of OTUB1 drastically stabilizes and activates p53, leading to apoptosis and marked inhibition of cell proliferation in a p53-dependent manner (Sun et al., 2012)