Description
IKBKB is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. The activity of IKBKB is stimulated by TNF and IL1 and IKBKB forms a heterodimer that interacts with NIK. Overexpression of catalytically inactive IKBKB blocks cytokine-induced NF-kappa-B activation. Aspirin and sodium salicylate can specifically inhibit IKBKB activity in vitro and in vivo by binding to IKBKB to reduce ATP binding