Description
Olfactomedin-Like Protein 3 (OLFML3) belongs to the OLFML3 family. OLFML3 is a secreted protein and contains one olfactomedin-like domain. In term placenta, OLFML3 is mainly localized extracellularly surrounding the syncytiotrophoblastic cells. OLFML3 is highly expressed in the placenta, moderate expressed in the liver and heart, with fairly weak expression in other tissues. It is shown that OLFML3 may have matrix-related function involved in human placental and embryonic development, or it may play a similar role in other physiological processes. In addition, OLFML3 plays an essential role in dorso-ventral patterning during early development