Description
Ribosome-Rreleasing factor 2 Mitochondrial (GFM2) is a member of the GTP-binding elongation factor family. Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. But it is not involved in the GTP-dependent ribosomal translocation step during translation elongation. GFM2 is widely expressed in many tissues and localizes to the mitochondrion. The role of GFM2 in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in at least three known transcript variants encoding distinct isoforms