Description
As the initiator Met is cleaved, Alpha Nmethyltransferase melthylates the Nterminus of target proteins containing the N terminal motif [Ala/Pro/Ser]ProLys. In the alphaamino group of Ala or Ser residue of [AlaSer]ProLys motif and mono or dimethylation of Pro in the ProProLys motif, AlphaNmethyltransferase catalyzes mono, di or trimethylation. NTM1 is responsible for the N terminal methylation of ribosomal protein, such as RPL12A, RPL12B, RPS25A, RPS25B