Description
Description: Recombinant human IL-2 produced in Yeast is a single, non-glycosylated, polypeptide chain containing 133 amino acids, one pair of disulfide bond and with 125 cys. aa. mutated to Ala aa, having a molecular mass of approximately 15.4kD.
Introduction: Human IL-2 (also known as TCGF) is an about 15.4KD factor produced mainly by activated CD4+ T cells. IL-2 induces cell cycle progression of resting cells in an antigen non-specific manner and allows clonal expansion of activated T cells. IL-2 also acts on activated B cells, monocytes, NK, LAK cells, and on oligodendroglial cells in vitro. In addition, IL-2 plays a role in hematopoiesis, tumor surveillance and anti-inflammatory reactions and hence is a central regulator of the immune response. Non-glycosylated IL-2 is biologically active. Recombinant human IL-2 is biologically active and can promote proliferation of T lymphocytes in culture.
IL-2 has been tested in many clinical trials as an immunotherapy for the treatment of cancers, chronic viral infections and as adjuvants for vaccines