Description
Lyn, a member of Src-family tyrosine kinases, is widely expressed in a variety of organs, tissues and cell types, including epithelial, hematopoietic and neuronal cells, and has an important role in signal transduction at the cytoplasmic face of the plasma membrane. The Lyn kinase domain is also required for targeting of Lyn to caveolin-positive Golgi membranes, which suggests that this domain has a crucial role in Lyn trafficking in addition to its role in catalysis of substrate tyrosine phosphorylation