TRAIL, R1 specific, soluble, Recombinant, Human (TRAIL, Apo-2L, TNFSF10, CD253) MBS635549 from MyBioSource.com

Description

TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB

Product Specs
ItemTRAIL, R1 specific, soluble, Recombinant, Human (TRAIL, Apo-2L, TNFSF10, CD253)
CompanyMyBioSource.com
Price $625.00Supplier Page View Company Product Page
Catalog NumberMBS635549
Size0.05 mg
FormatIn 20mM HEPES, pH 7.9, 120mM NaCl, 0.01% Tween 20, 1% sucrose, 1mM DTT
PurityHighly Purified
>98% (SDS-PAGE)
Molecular Weight~26kD
Molecule NameTRAIL, R1 specific, soluble
ImmunogenBinds to human TRAIL receptor 1 (DR4), but not human TRAIL-R2 (DR5). Binding to TRAIL-R3, -R4 and osteoprotegrin (OPG) are not tested
NCBI Full Gene NameTNF receptor superfamily member 10a
NCBI Gene AliasesTRAILR-1, TRAILR1, APO2, DR4, CD261
Source/Expression SystemHuman, E Coli

Sequence

The extracellu lar domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide and contains aa substituti ons, which generate a binding specificit y towards TRAIL receptor 1 (TRAIL-R1; DR4)

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