Description
Neutrophil Elastase (ELAn also known as polymorphonuclear leukocyte elastase, is a serine protease belonging to the chymotrypsin family. localecf primarily In the azurophil granules of polymorphonuclear leukocytes, EtA2 function is the degradation of many extracellular matrix macromolecules. alpha· 1 AntitrYpsin (Serpin A 1) and secretory leukocyte protease inhibitor (SLPI) have been shown to inhibit ELA2 activity. This protein may be involved in lung emphysema cystic fibrosis, the adult respiratory distress syndrome CARDS), rheumatoid arthritis, tumor invasion and infectious diseases. The purified recombinant mouse ELA2 does not contain the last five amino acid residues of the deduced amino acid sequence (NP _056594).
Murine myeloma cell line, NSO-derived Ser27-Arg260 with a C-terminallO-His tag (NP _056594)