Description
Information: Human CD137 Ligand is a type II transmembrane protein constitutively expressed by monocytes, B cells and neuroblastoma cells (1). The interaction of CD137 (4-1BB) and CD137L can supply a costimulatory signal to T cells through CD137. This costimulus seems to be more effective for CD8+ effector T cells than for CD4+ helper T cells (3). The interaction can also induce monocyte activation through CD137L (2). Human CD137L-muCD8 binds to CD137 on human cells and is blocked by CD137-huIg fusion protein