Description
Recombinant fragment human TSHR protein with 66 kDa with his tag.
Thyroid stimulating hormone receptor (TSHR), also known as Thyrotropin receptor is a member of the leucine-rich reapeat-containing G protein-coupled receptors. G protein-coupled receptors (GPCRs) are the largest family of plasma membrance receptors. They mediate the effects of several endogenous cues and serve as important pharmacological targets. TSHR is primary found on the surface of the thyroid epithelial cells. Both TSHR and its ligand TSH have evolved to accquire specificity, minimize cross-reaction to other glycoprotien hormone receptors, and modulate cognate interaction (and thereby thyrotropic activity)