Description
Recombinant human INFbeta 1b protein with molecular weight 19 kDa.
Fibroblast interferon, or interferon-beta has 45% homology at the nucleotide level and 29% at the amino acid level with leukocyte interferon, or interferon-alpha. RANKL induces the IFN-beta gene in osteoclast precursor cells, and that IFN-beta inhibits the differentiation of osteoclasts by interfering with the RANKL-induced expression of c-Fos, an essential transcription factor for the formation of osteoclasts. This IFN-beta gene induction mechanism is distinct from that induced by virus, and is dependent on c-Fos itself