Description
Recombinant full-length human CDKL3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: CDKL3 or cyclin-dependent kinase-like 3 is a member of cyclin-dependent protein kinase (CDK) family which is highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and is known to be important regulators of cell cycle progression and cellular proliferation. CDKL3 is a novel CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases (1). CDKL3 is identified as a gene absent in leukemic patients with chromosome 5q deletion and this loss may be an important determinant of dysmyelopoiesis (2)