Description
Recombinant full length human SNCA was expressed in E. coli cells using an N-terminal His tag.
Scientific Background: SNCA is a member of the synuclein family which also includes beta- and gamma-synuclein. These proteins are abundantly expressed in the brain and alpha- and beta-synuclein selectively inhibit phospholipase D2 which is a highly conserved protein that is also abundant in neurons, especially presynaptic terminals (1). SNCA gene is not a major risk factor in familial Parkinson disease (2). SNCA may serve to integrate pre-synaptic signaling and membrane trafficking and SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease