Description
Recombinant full-length human p38gamma was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Scientific Background: P38γ is a member of the p38 MAPK family which is activated in response to stress (1). p38-gamma gene was mapped to 22q13.3 and functions as a signal transducer during differentiation of myoblasts to myotubes. Enforced localization of p38γ in the nucleus or cytoplasm markedly attenuates the ability of the kinase to induce cell cycle arrest in fibroblasts. p38γ increases basal glucose uptake and decreases DNP- and contraction-stimulated glucose uptake, partially by affecting levels of glucose transporter expression in skeletal muscle (2)