Description
Leptin exerts its activity through specific membrane receptor, the obesity or leptin receptor (LEP-R), which is assigned to class I cytokine receptor family. Six splice variants of LEP-R have been identified up to now; a long isoform, four short isoforms discriminated by the different lengths of intracellular domain and the secreted isoform, which modulates blood leptin. According to the current knowledge, leptin-signaling pathway is mainly transduced by janus kinases/signal transducers and activators of transcription, mitogen- activated protein kinase and phosphatidylinositol 3- Kinase (PI3K) -signaling pathways