Description
Recombinant human ULK4 (1-616) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: ULK4, or Unc-51-like kinase 4, is a Ser/Thr protein kinase that is a member of the APG1/unc-51/ULK1 subfamily. ULK4 contains five HEAT repeats and a catalytic kinase domain. The ULK4 gene is conserved in many species including chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana, and rice (1). ULK4 has been implicated as a gene involved in the development of hydrocephalus (2). This neurologic disorder in animal models is being used to elucidate factors responsible for the excessive accumulation of cerebrospinal fluid in hydrocephalic humans